Evidence map›Paper›PMID 42615684›Full record

SynthesisBrazilian oral research2026

Comparative efficacy of violet light, bleaching gel, or their combination, in in-office bleaching: a systematic review and network meta-analysis.

Michael Willian Favoreto, Renata Maria Oleniki Terra, Camila Mendes Camargo, Bianca Maran, Vanessa Cavalli, Ana Cláudia Chibinski, Alessandro Dourado Loguercio, Alessandra Reis

Abstract readSystematic ReviewNetwork Meta-AnalysisComparative Study
In one paragraph

Synthesis in Brazilian oral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael Willian FavoretoUniversidade de São Paulo - FOUSP, School of Dentistry, Department of Restorative Dentistry, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-0800-7915
Renata Maria Oleniki TerraUniversidade Estadual de Ponta Grossa - UEPG, School of Dentistry, Department of Restorative Dentistry, Ponta Grossa, PR, Brazil.ORCID http://orcid.org/0000-0003-1450-9361
Camila Mendes CamargoUniversidade Estadual de Ponta Grossa - UEPG, School of Dentistry, Department of Restorative Dentistry, Ponta Grossa, PR, Brazil.ORCID http://orcid.org/0009-0000-9001-8594
Bianca MaranUniversidade Estadual do Oeste do Paraná - Unioeste, School of Dentistry, Department of Restorative Dentistry, Cascavel, PR, Brazil.ORCID http://orcid.org/0000-0002-1934-6656
Vanessa CavalliUniversidade de Campinas - FOP, School of Dentistry, Department of Restorative Dentistry, Piracicaba, SP, Brazil.ORCID http://orcid.org/0000-0002-9459-1926
Ana Cláudia ChibinskiUniversidade Estadual de Ponta Grossa - UEPG, School of Dentistry, Department of Restorative Dentistry, Ponta Grossa, PR, Brazil.ORCID http://orcid.org/0000-0001-7072-9444
Alessandro Dourado LoguercioUniversidade Estadual de Ponta Grossa - UEPG, School of Dentistry, Department of Restorative Dentistry, Ponta Grossa, PR, Brazil.ORCID http://orcid.org/0000-0001-9880-4856
Alessandra ReisUniversidade Estadual de Ponta Grossa - UEPG, School of Dentistry, Department of Restorative Dentistry, Ponta Grossa, PR, Brazil.ORCID http://orcid.org/0000-0001-6798-2094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review and network meta-analysis aimed to determine whether the use of violet light alone (VIOL) or its combination with bleaching gels (BGVIOL) results in superior bleaching efficacy compared to bleaching gel alone (BG). Randomized clinical trials (RCTs) were identified through searches in PubMed, Cochrane Central, LILACS/BBO, SCOPUS, Web of Science, EMBASE, and gray literature sources in March, 2025. Eligible RCTs compared in-office bleaching using BG, or VIOL, or BGVIOL. The Cochrane risk of bias tool was used to evaluate the risk of bias (RoB 2.0) of the eligible RCTs. A random-effects Bayesian mixed treatment comparison model evaluated color change (ΔE*ab and ΔSGU/final SGU), and risk and intensity of tooth sensitivity (TS). Ranking probabilities were evaluated using the surface under the cumulative ranking curve, and the certainty of evidence was appraised following the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 4,963 records, 17 RCTs were included, 11 of which had a high RoB. Analysis of ΔE*ab revealed significant mean differences (MD) and 95% credibility interval (95%Crl) for the full dataset for BGVIOL vs. BG (MD = 3.13; 95%CrI: 1.33 to 4.97), but not with the subset of data that excluded studies with high RoB (MD = 2.36; 95%CrI: -0.74 to 5.34). Color change in ΔSGU did not differ among groups. VIOL showed the lowest risk and intensity of TS. Color change achieved with BG and BGVIOL was higher than that obtained with VIOL. VIOL yielded lower risk and intensity of TS. The certainty of the evidence supporting these findings is low or very low.

Indexed as

Tooth BleachingTooth Bleaching AgentsDentin SensitivityGelsHumansRandomized Controlled Trials as TopicTreatment OutcomeGelsTooth Bleaching Agents

Identifiers

PMID42615684
PMCPMC13475733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.