Evidence map›Paper›PMID 42615634›Full record

ArticleMicrobiology spectrum2026

Decoupling virulence from growth: a synthetic α-helical peptide suppresses

Naman Tandon, Keelee Storrud, Neta Filip Granit, Andrei Gabrielian, Curtis Thiele, Chadwick Hillman, Yixiang Zhang, Jared McGourty, Giorgi Zaalishvili, Vinod Nair and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Naman TandonLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Keelee StorrudLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0009-0002-1268-2988
Neta Filip GranitOffice of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Andrei GabrielianOffice of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Curtis ThieleMicroscopy Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Chadwick HillmanLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Yixiang ZhangProtein Chemistry Section, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Jared McGourtyLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Giorgi ZaalishviliIvane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
Vinod NairMicroscopy Unit, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Darrell HurtOffice of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Malak PirtskhalavaIvane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
Olivia Steele-MortimerLaboratory of Bacteriology, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0002-3744-4217

Funding

Division of Intramural Research, National Institute of Allergy and Infectious Diseases ZIA AI000909
6 · The paper itself

Abstract

Cationic antimicrobial peptides (CAMPs) can alter bacterial physiology at concentrations below those required to inhibit growth, including modulation of virulence gene expression. In

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial ProteinsMembrane ProteinsSalmonella typhimuriumGene Expression Regulation, BacterialHumansMicrobial Sensitivity TestsPolymyxin BVirulenceAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial ProteinsMembrane ProteinsPolymyxin BSpi1 protein, Salmonellaantimicrobial peptideanti-virulenceSalmonella enterica serovar Typhimuriumtype III secretion systemvirulence regulation

Identifiers

PMID42615634
PMCPMC13689458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.