Evidence map›Paper›PMID 42615444›Full record

ReviewJACC. CardioOncology2026

Cerebrovascular Accident Risk in Survivors of Head and Neck Cancer: JACC CardioOncology State-of-the-Art Review.

Courtney Pisano, Jenica Upshaw, Benjamin Colvard, David Zidar, Ryan Hughes, Karem Harth, Sahil Parikh, Theodore Arsenault, Kamal Chemali, Natalie Evans and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. CardioOncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Courtney PisanoDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA.
Jenica UpshawDivision of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Benjamin ColvardDivision of Vascular Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
David ZidarDivision of Cardiology, Department of Medicine, Cleveland Clinic Foundation and Case Western Reserve University, Cleveland, Ohio, USA.
Ryan HughesDepartment of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Karem HarthDivision of Vascular Surgery, Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Sahil ParikhDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.
Theodore ArsenaultDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA.
Kamal ChemaliDepartment of Neurology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Natalie EvansDivision of Cardiology, Department of Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Matthew MirskyDivision of Oncology, Department of Medicine, University Hospitals Sediman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA.
Eli ScherDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA.
Christopher MurphyDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA.
Logan ChoDivision of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.
Jennifer DorthDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, Ohio, USA. Electronic address: Jennifer.dorth@uhhospitals.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancer survivors treated with radiation therapy have a substantially higher long-term risk of cerebrovascular accident than the general population, driven by radiation-related carotid artery injury, baseline cardiovascular risk factors, and the effects of chemotherapy. Carotid stenosis progresses over time, making regular ultrasound screening important for early detection and intervention. Statin therapy during and after radiation therapy, along with intensive blood pressure management, may reduce cerebrovascular event rates. Guidelines increasingly recommend integrating cardiovascular risk assessment and prevention into cancer care, with special consideration of radiation- and chemotherapy-related risk and aggressive risk factor modification. Multidisciplinary strategies, including medication, lifestyle interventions, and timely revascularization for progressive or symptomatic carotid stenosis, are essential to improve outcomes and minimize cerebrovascular accident risk in head and neck cancer survivors.

Indexed as

cancer survivorshipcardiovascular preventioncarotid artery diseaseCVA riskhead and neck cancerradiation physicsradiation therapyrisk prediction

Identifiers

PMID42615444
PMCPMC13492441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.