ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo.
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao and 3 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Qingquan XiaoState Key Laboratory of Advanced Drug Delivery and Release Systems, Jinhua Institute of Zhejiang University, School of Pharmacy, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0003-3921-9395 Zhijin TianState Key Laboratory of Advanced Drug Delivery and Release Systems, Jinhua Institute of Zhejiang University, School of Pharmacy, Zhejiang University, Hangzhou, China.
Luqi WengState Key Laboratory of Advanced Drug Delivery and Release Systems, Jinhua Institute of Zhejiang University, School of Pharmacy, Zhejiang University, Hangzhou, China.
Kun XuInternational Joint Agriculture Research Center for Animal Bio-Breeding of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0001-5714-9090 Dingyi HanCenter for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences, Shanghai, China.
Junnan LiSchool of Pharmacy, Hangzhou Medical College, Hangzhou, China.
Shangpu LiInternational Joint Agriculture Research Center for Animal Bio-Breeding of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Qijing ZhangInternational Joint Agriculture Research Center for Animal Bio-Breeding of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xiaohui ZhaoState Key Laboratory of Advanced Drug Delivery and Release Systems, Jinhua Institute of Zhejiang University, School of Pharmacy, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-5696-5974 Guoling LiZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Yinghui WeiInternational Joint Agriculture Research Center for Animal Bio-Breeding of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0002-6642-1559 Zhen GuState Key Laboratory of Advanced Drug Delivery and Release Systems, Jinhua Institute of Zhejiang University, School of Pharmacy, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0003-2947-4456 Funding
Jinhua Science and Technology Plan Projects 2026-3-097National Key R&D Program of China 2021YFA0909900National Natural Science Foundation of China 32441080National Natural Science Foundation of China 3250120657National Natural Science Foundation of China 32501335National Natural Science Foundation of China 52233013Zhejiang Provincial Natural Science Foundation of China LQN26C050001
6 · The paper itselfAbstract
Despite the promise of DNA base editors for diverse genome editing applications, their utility remains constrained by off-target effects, which are exacerbated by short spacers in miniature systems and the large size of Cas9-derived editors, which impedes adeno-associated virus (AAV) delivery. Here, guided by structural insights into a compact Cas9d nuclease from Deltaproteobacteria, we developed an efficient Cas9d system (Cas9d
Indexed as
base editorCRISPR‐Cas9dgene editingPcsk9 geneTyr gene
Identifiers
PMID42615363
PMCPMC13487866
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