ReviewArchivos peruanos de cardiologia y cirugia cardiovascular
Diagnosis of ATTR cardiac amyloidosis by
Review in Archivos peruanos de cardiologia y cirugia cardiovascular. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: To describe the application of the noninvasive diagnostic algorithm for transthyretin cardiac amyloidosis (ATTR) using Materials and Methods: A descriptive case series was conducted between 2024 and 2025 at the Nuclear Medicine Department of Hospital Nacional Guillermo Almenara Irigoyen (Lima, Peru). Six patients with clinical suspicion of ATTR referred from Cardiology were included. A standardized protocol was applied, consisting of the administration of 20 mCi of Results: The average age was 69.7±10.3 years; 66.7% were male. All patients had left ventricular hypertrophy and 83.3% had heart failure. Three patients (50%) showed grade 2-3 uptake; among them, two (33.3%) met criteria for noninvasive ATTR diagnosis (grade 3, positive SPECT, and negative monoclonal screening), with H/CL values above diagnostic cutoffs. One grade 2 case had an IgG kappa monoclonal component and was classified as inconclusive. Three patients (50%) had grade 1 uptake, considered equivocal, with H/CL values below diagnostic thresholds. SPECT was essential to confirm true myocardial uptake and avoid overinterpretation in borderline cases. Conclusions: Structured application of the noninvasive diagnostic algorithm with
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