ArticleSchizophrenia bulletin open2026
Potential Mechanisms of Change in Virtual Reality-based Cognitive Behavioural Therapy and Standard Cognitive Behavioural Therapy for Schizophrenia-Related Paranoia: A Mediation Analysis from the FaceYourFears Trial.
Article in Schizophrenia bulletin open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Background and Hypothesis: Cognitive models conceptualize paranoia in schizophrenia spectrum disorders as driven and maintained by mechanisms, which can be targeted by cognitive behavioral therapy for paranoia (CBTp). This study examined potential mechanisms as mediators. Safety behaviors, belief inflexibility, and core beliefs about self and others were hypothesized to differentially mediate outcomes in virtual reality-based CBTp (VR Study Design: This secondary analysis of the FaceYourFears trial included a per-protocol sample with complete data (VR Study Results: Pearson correlations of change scores showed that positive safety behaviors and negative self- and others-related core beliefs were associated with paranoia across both interventions. Regression analyses without covariate adjustment showed no significant between-group differences, except for belief inflexibility ( Conclusions: No mediators differed between interventions, and no hypotheses were supported. These results suggest similar mechanistic pathways in CBTp and VR
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