ArticleIEEE transactions on radiation and plasma medical sciences2026
Experimental Evaluation of DE-SPECT: A Hyperspectral SPECT System for Region-Selective 3-D Gamma-Ray Spectroscopy.
Article in IEEE transactions on radiation and plasma medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
This study presents an experimental evaluation of the Dynamic Extremity SPECT (DE-SPECT) system, specifically engineered for precise, region-selective gamma-ray spectroscopy in the diagnosis of Peripheral Vascular Disease (PVD) in lower extremities. The system incorporates Cadmium Zinc Telluride (CZT) imaging spectrometers and dynamic dual-field-of-view (FOV) collimators to facilitate comprehensive, multifunctional molecular imaging. The CZT detectors, with Depth of Interaction (DOI) capabilities, deliver an exceptional energy performance across a wide energy range up to 600 keV. The novel dual-FOV aperture system allows selective imaging with two configurations: a 28-cm diameter wide FOV suitable for dual-leg or scout imaging and a 16-cm diameter high-resolution, and high-sensitivity (HR-HS) FOV designed for single-leg or focused imaging. Utilizing uniform phantoms, resolution phantoms, and multi-tracer phantoms, we experimentally assessed the system's sensitivity, spatial resolution, and multi-tracer imaging capabilities. Spatial resolutions were approximately 6 mm in HR-HS-FOV mode and between 8 mm to 10 mm in wide-FOV mode. Peak-to-Valley ratios, indicative of image clarity, improved with enhanced DOI resolutions, rising from 1.03 to 1.22. The system's ability to perform multi-tracer imaging, essential for deriving multifunctional molecular information, further highlights its potential to significantly enhance diagnostic accuracy for PVD.
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