Evidence map›Paper›PMID 42614910›Full record

ArticleFungal biology reviews2025

Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens.

Joris A Alkemade, Nichola J Hawkins, Elena Baraldi, Alan G Buddie, Helen M Cockerton, Isabel Corkley, Bart A Fraaije, Ester Gaya, Danna R Gifford, Florian Hartig and 9 more

Abstract read
In one paragraph

Article in Fungal biology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Spray-Induced Gene Silencing (SIGS) of Dual-Target Genes (Journal of fungi (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Targeted Suppression of the Tomato PathogenJournal of fungi (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Joris A Alkemade *Department of Biology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-1477-2936
Nichola J Hawkins *National Institute of Agricultural Botany (NIAB), Cambridge, UK.ORCID https://orcid.org/0000-0003-3389-0436
Elena BaraldiDepartment of Agricultural and Food Sciences, University of Bolonga, Bologna, Italy.ORCID https://orcid.org/0000-0001-9496-0093
Alan G BuddieCAB International (CABI), Ascot, UK.ORCID https://orcid.org/0000-0002-7677-9300
Helen M CockertonSchool of Biosciences, University of Kent, Canterbury, UK.ORCID https://orcid.org/0000-0002-7375-1804
Isabel CorkleySustainable Agricultural Systems, RSK ADAS Ltd, Wolverhampton, UK.ORCID https://orcid.org/0000-0003-3783-3180
Bart A FraaijeWageningen University & Research, Wageningen, the Netherlands.ORCID https://orcid.org/0000-0001-8176-2258
Ester GayaComparative Plant and Fungal Biology, Royal Botanic Gardens Kew, Richmond, UK.ORCID https://orcid.org/0000-0001-6404-4297
Danna R GiffordSchool of Biological Sciences, Faculty of Biology Medicine & Health, The University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-4990-8816
Florian HartigTheoretical Ecology, University of Regensburg, Regensburg, Germany.ORCID https://orcid.org/0000-0002-6255-9059
Kostya KanyukaNational Institute of Agricultural Botany (NIAB), Cambridge, UK.ORCID https://orcid.org/0000-0001-6324-4123
Aline KochTheoretical Ecology, University of Regensburg, Regensburg, Germany.ORCID https://orcid.org/0009-0004-4763-1800
Jonatan Niño SánchezDepartment of Plant Production and Forest Resources, Sustainable Forest Management Research Institute (iuFOR), College of Agricultural Engineering (ETSIIAA), University of Valladolid, Palencia, Spain.ORCID https://orcid.org/0000-0002-0356-9871
Gail M PrestonDepartment of Biology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-3882-4438
Michael F SeidlTheoretical Biology & Bioinformatics, Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-5218-2083
Pietro D SpanuImperial College, London, UK.ORCID https://orcid.org/0000-0001-8928-6049
Bernhard T WernerLiebig University Giessen, Giessen, Germany.ORCID https://orcid.org/0000-0002-8787-6050
Joy LyuDepartment of Biology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0009-0001-5393-6609
Timothy G Barraclough *Department of Biology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-8084-2640

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crop protection against fungal pathogens is essential to prevent crop losses and maintain food security. Current crop protection relies heavily on chemical fungicides. However, rapid evolution of fungicide resistance, the constant appearance of new pathogens, and legislation against chemical pesticides due to concerns regarding their impact on human health and the environment, mean new crop protection strategies are urgently required. One elegant solution is double-stranded RNA-based crop protection, which aims to silence selected genes in the pathogen to reduce crop damage. This technology brings the promise of targeting specific genes, which could be chosen to maximise protection, minimize off-target effects and reduce the risk of resistance evolution. Here we discuss strategies for successful use of this novel technology based on lessons learned from fungicide resistance and recent discoveries in fungal evolution derived from genome-sequencing.

Indexed as

Crop protectionEvolutionary genomicsFungal pathogensFungicide resistanceRNAi

Identifiers

PMID42614910
PMCPMC7619375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.