ArticleJournal of cardiovascular echography
Mechanism of Left Ventricular Dysfunction due to Permanent Pacemaker: An Analysis of miR-155, sTNFR-2, MMP-9, N-Cad, and ZO-1.
Article in Journal of cardiovascular echography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Total atrio-ventricular block is a lethal condition and is an indication of permanent pacemaker (PPM) implantation. Although PPM is lifesaving, patients frequently develop left ventricular dysfunction (LVd) which is traditionally detected with left ventricular ejection fraction (LVEF). Global longitudinal strain (GLS) may detect LVd before a decrease in LVEF. Cellular mechanisms of LVd following PPM implantation remain poorly understood. Aims: This study aimed to evaluate biomarker changes associated with the development of LVd following PPM implantation. Settings and Design: This quasi-experimental study was conducted on adult patients undergoing PPM implantation. Subjects and Methods: Echocardiography parameters and blood samples were obtained before PPM implantation (P0), at 1 month (P1) and at 3 months (P3). Patients divided into two groups (decreased GLS vs. unchanged GLS group) based on Delta P1 to P3 GLS. Biomarkers (miR-155, sTNFR-2, MMP-9, N-Cad, and ZO-1) concentration at P0 are compared to P1 and P3 between groups. Statistical Analysis Used: Data were evaluated using nonparametric and parametric tests, repeated-measures analyses, and multivariate modeling as appropriate. Results: A total of 42 patients were included. There is a significant difference of P1 sTNFR-2 concentration between decreased GLS group and unchanged GLS group (1947.75 [standard deviation (SD) 103.80] vs. 1778.01 [SD 237.16]; Conclusion: STNFR-2 may represent an early inflammatory signal associated with relative GLS deterioration following permanent pacemaker implantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.