ArticleMedicine and pharmacy reports2026
Fibrosis-4 index utility for screening liver fibrosis and its association with degenerative complications in patients with type 2 diabetes mellitus: a monocentric study.
Article in Medicine and pharmacy reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Backgrounds: The fibrosis-4 index is a simple biomarker tool widely recommended to diagnose advanced hepatic fibrosis in patients with type 2 diabetes mellitus (T2DM). The primary aim of this study was to assess liver fibrosis risk among type 2 diabetes mellitus patients using the Fib-4 score, secondary to compare the prevalence of degenerative complications between patients according to Fib-4 index risk, and to evaluate the prevalence of metabolic dysfunction-associated-steatotic liver disease in our population. Methods: This is a descriptive-analytical cross-sectional study including 600 patients with type 2 diabetes mellitus who were followed at the Endocrinology-Diabetology and Nutrition Department of a university hospital center, for a period of 8 years and 10 months from January 2016 to October 2024. Results: The mean age in our population was 59±12.8 years. The median duration of diabetes was 6.4 years (1-15 years) with a median HbA1c value of 10.2±2.7%. Overweight and obesity were found in 39.2% and 34.5% of patients respectively, with a mean BMI of 28.2±5.9 kg/m Conclusion: Fibrosis-4 index should be considered for routine screening of liver fibrosis in patients with type 2 diabetes mellitus. This simple and cost-effective tool can help identify patients at high risk. The current study highlighted the benefits of using this score among patients with T2DM and supported the high prevalence of microvascular complications and ischemic heart disease among patients with Fib-4 index ≥1.3. Furthermore prospective studies are required to evaluate the incidence outcomes in this population.
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