ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Harmonizing biofluid specimen collection and biomarker quantification in Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Harmonizing biofluid specimen collection and biomarker quantification in Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
introductionMulticenter clinical studies inherently face challenges in maintaining consistency across sites. Here we share the design and implementation of standard operating procedures (SOPs) for the Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study.
methodsThe Repository Core implements harmonized protocols for biospecimen collection and preparation. Pre-, intra-, and post-analytical factors influencing sample integrity and data reliability are addressed. Stringent measures are applied to obtain reproducible biomarker data.
resultsRigorous post-analytical quality control ensures assay variabilities within acceptable limits. Interim analyses, presented as proof of concept, show differences in selected plasma biomarkers across sex and race/ethnicity after covariate adjustment. These efforts establish a strong foundation for the high-quality data generated in DVCID, supporting reliability of downstream analyses. DISCUSSION: This work demonstrates a standardized framework to enhance data comparability, aiming to inform and facilitate future multicenter biomarker studies. Interim findings also highlight the potential need for ethnoracially tailored cut-offs when interpreting blood-based biomarker data.
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Registered trials
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