Evidence map›Paper›PMID 42614663›Full record

ArticleAdvances in urology2026

Clinical Characteristics, Long-Term Outcomes, and Prognostic Factors in High-and Very High-Risk Prostate Cancer: A 25-Year Institutional Cohort Study.

Tomoyuki Shimabukuro, Hidekazu Tanaka, Masahiro Tanabe, Takanori Tokunaga, Kosuke Shimizu, Nakanori Fujii, Keita Kobayashi, Toshiya Hiroyoshi, Hiroshi Hirata, Koji Shiraishi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tomoyuki ShimabukuroDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0009-0009-2536-0321
Hidekazu TanakaDepartment of Radiation Oncology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0000-0002-8673-5707
Masahiro TanabeDepartment of Radiology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.
Takanori TokunagaDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0009-0003-6703-9268
Kosuke ShimizuDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0000-0002-2892-3750
Nakanori FujiiDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.
Keita KobayashiDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0000-0001-9279-3156
Toshiya HiroyoshiDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.
Hiroshi HirataDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0009-0004-1063-8646
Koji ShiraishiDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan, yamaguchi-u.ac.jp.ORCID https://orcid.org/0000-0002-3278-7747

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: High- and very high-risk prostate cancer (hvPCa) is associated with substantial prostate cancer-specific mortality, making optimal treatment selection challenging. This study reevaluated our 25-year institutional experience with hvPCa to assess long-term oncological outcomes and identify prognostic factors associated with survival. Methods: We retrospectively analyzed 220 patients with hvPCa reclassified according to the latest National Comprehensive Cancer Network guidelines. Of these, 66 underwent radical prostatectomy (RP), 52 received radiotherapy plus androgen deprivation therapy (RT + ADT), and 102 received primary ADT. Long-term oncological outcomes were compared across treatment modalities and risk groups. Prognostic factors associated with prostate cancer-specific survival (PCSS) were evaluated using Cox proportional hazards models. Results: The median age was 71 years, and the median follow-up duration was 88 months. During follow-up, 49 patients (22.3%) died from any cause, and 19 (8.6%) died from prostate cancer. Among high-risk patients, overall survival was significantly better in the RP group than in the ADT group (hazard ratio [HR]: 4.812; 95% confidence interval [CI]: 1.832-12.635; Conclusions: Poorer ECOG performance status and biochemical recurrence were independently associated with worse PCSS in patients with hvPCa. These findings highlight the prognostic importance of patient functional status in addition to conventional tumor-related factors and may contribute to improved risk stratification and individualized treatment selection.

Indexed as

biochemical recurrenceECOG performance statushigh-risk prostate cancervery high-risk prostate cancer

Identifiers

PMID42614663
PMCPMC13482177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.