ArticleACS pharmacology & translational science2026
A Partition-Controlled Kinetic Model for Drug Release from Polymeric Nanocapsules: Resolving the Solubility Paradox.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mathematical descriptions of drug release from polymeric nanocapsules are commonly based on first-order kinetics derived from the Noyes-Whitney equation. However, previous formulations implicitly predict that increasing drug solubility in the oily core accelerates release, which contradicts experimental evidence. In this work, we revisit the modeling framework and derive a physically consistent equation based on diffusion through the polymeric shell coupled with partition equilibrium at the oil-water interface. The resulting model shows that release kinetics are governed by the dimensionless partition-solubility group
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