ArticleACS pharmacology & translational science2026
Pharmacological Blockade of Hypoxia-Driven Autophagy: A Therapeutic Strategy to Limit Endothelial Activation and Thrombosis.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thrombosis, a major underlying cause of cardiovascular disorders, is frequently initiated by endothelial cell (EC) activation, which facilitates platelet adhesion and subsequent clot formation. Although vascular injury is a well-established trigger, accumulating evidence implicates hypoxia as an additional determinant of thrombus development. In our previous study, we demonstrated that hypoxia associated with high altitude can promote autophagy-induced platelet aggregation. However, the contribution of ECs to such thrombosis under comparable hypoxic conditions (10%) remains poorly understood. In this study, using ECs isolated from rat aorta
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