Evidence map›Paper›PMID 42614396›Full record

ArticleFrontiers in immunology2026

Aquamin, a marine derived multi-mineral, attenuates toll-like receptor-mediated inflammatory responses in macrophages.

Emmanouil Lioudakis, Sakshi Hans, Denise M O'Gorman, Shane O'Connell, Margaret Lucitt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emmanouil LioudakisDepartment of Pharmacology and Therapeutics, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Sakshi HansDepartment of Pharmacology and Therapeutics, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Denise M O'GormanMarigot Research Centre, Sycamore Court, Tralee, Co., Kerry, Ireland.
Shane O'ConnellMarigot Research Centre, Sycamore Court, Tralee, Co., Kerry, Ireland.
Margaret LucittDepartment of Pharmacology and Therapeutics, School of Medicine, Trinity College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLRs) play a central role in innate immune responses through recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Activation of TLRs leads to the induction of inflammatory cytokines via myeloid differentiation primary response 88 (MyD88)- and TIR-domain-containing adaptor-inducing interferon-β (TRIF)-dependent signaling pathways. Aquamin, a multi-mineral supplement derived from the marine red algae

Indexed as

Anti-Inflammatory AgentsInflammationMacrophagesToll-Like ReceptorsAdaptor Proteins, Vesicular TransportAnimalsCytokinesHumansInnate Immunity RecognitionLeukocytes, MononuclearLipopolysaccharidesMiceSignal TransductionToll-Like Receptor AgonistsAdaptor Proteins, Vesicular TransportAnti-Inflammatory AgentsCytokinesLipopolysaccharidesToll-Like Receptor AgonistsToll-Like ReceptorsAquamininnate immunitymacrophagesmarine multi-mineraltoll-like receptors

Identifiers

PMID42614396
PMCPMC13481773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.