ArticleFrontiers in microbiology2026
Wumei extract modulates inflammation and oral microbiota for radiation-induced oral mucositis.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Radiation-induced oral mucositis (RIOM) is a common and debilitating complication of radiotherapy for head and neck cancer. Although Wumei extract (WME, Methods: A mouse model of radiation-induced tongue dorsal mucositis (RITDM) was established using fractionated low-dose irradiation followed by a terminal high dose. Mice were treated with saline or WME, and outcomes including body weight, ulcer severity, histopathology, proliferation, apoptosis, and inflammatory cytokine expression were evaluated. Oral microbiota changes were analyzed using 16S rRNA and ITS sequencing. Results: WME significantly attenuated radiation-induced body weight loss, reduced ulcer severity, and preserved epithelial structure. It enhanced epithelial proliferation, reduced apoptosis, and downregulated TNF-α and IL-1β expression. Radiation enriched pro-inflammatory bacteria ( Conclusion: WME alleviates RIOM by supporting epithelial regeneration, suppressing apoptosis and inflammation, and promotes oral microbiota balance, suggesting its potential as a novel adjunctive therapy for patients undergoing head and neck radiotherapy.
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