Evidence map›Paper›PMID 42614302›Full record

ArticleFrontiers in pharmacology2026

Identification of a large

Marco Donatello Delcuratolo, Maria Grazia Rodriquenz, Franco Morelli, Tiziana Pia Latiano, Lucia Anna Muscarella, Simona Caporilli, Lorenza Pasqualini, Elisabetta De Santis, Vincenzo Giambra, Antonio Rinaldi and 12 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Marco Donatello Delcuratolo *Oncology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Maria Grazia Rodriquenz *Oncology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Franco MorelliOncology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Tiziana Pia LatianoOncology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Lucia Anna MuscarellaLung Cancer Research Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Simona CaporilliLife Sciences and Diagnostic Group, Agilent Technologies Italia S.p.A. Cernusco sul Naviglio, Milan, Italy.
Lorenza PasqualiniLife Sciences and Diagnostic Group, Agilent Technologies Italia S.p.A. Cernusco sul Naviglio, Milan, Italy.
Elisabetta De SantisHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Vincenzo GiambraHematopathology Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Antonio RinaldiMedicina Trasfusionale e Laboratorio Analisi, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.
Grazia CiavarellaMedicina Trasfusionale e Laboratorio Analisi, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.
Matteo FlorisDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Roberta MurruDepartment of Medical Genetics, Binaghi Hospital, ASL Cagliari, Cagliari, Italy.
Alessia MasciaUnit of Oncology and Molecular Pathology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Elena De MattiaExperimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano (PN), Italy.
Giovanni CanilExperimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano (PN), Italy.
Giuseppe FaniaMedicina Trasfusionale e Laboratorio Analisi, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.
Ana PopAmsterdam UMC, Vrije Universiteit Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, Netherlands.
Massimo CarellaMedical Genetics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
André van KuilenburgAmsterdam UMC, Vrije Universiteit Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, Netherlands.
Erika Cecchin *Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano (PN), Italy.
Giuseppe Miscio *Medicina Trasfusionale e Laboratorio Analisi, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fluoropyrimidines are widely used in the treatment of multiple neoplasms, but their use is limited by the risk of severe toxicity in patients with dihydropyrimidine dehydrogenase (DPD) deficiency. Current clinical guidelines recommend Case Description: We describe the case of a man with resected gastric adenocarcinoma, wild type for the Conclusion: This case highlights the limitations of routine

Indexed as

case reportDPD activityDPYD genefluoropyrimidine toxicitynext-generation sequencing

Identifiers

PMID42614302
PMCPMC13481457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.