Evidence map›Paper›PMID 42614274›Full record

ReviewCancer innovation2026

Advances in the Research of Nasopharyngeal Carcinoma: A Perspective.

Zishan Liang, Xian-Yue Zeng, Jia-Wei Lv, Guan-Qun Zhou, Ying Sun, Li Lin

Abstract readReview
In one paragraph

Review in Cancer innovation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zishan LiangDepartment of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou China.ORCID https://orcid.org/0009-0005-3096-1608
Xian-Yue ZengDepartment of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou China.
Jia-Wei LvDepartment of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou China.
Guan-Qun ZhouDepartment of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou China.
Ying SunDepartment of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou China.
Li LinDepartment of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The year 2025 marked significant advances in precision medicine for nasopharyngeal carcinoma (NPC). This review summarizes recent advances in treatment strategies aimed at addressing longstanding challenges in NPC management, including treatment-related toxicity, therapeutic resistance, and the limited precision of risk stratification. For locoregionally advanced NPC, a novel efficacy-enhancing and toxicity-minimizing strategy has emerged: toxicity minimizing involves replacing toxic concurrent cisplatin chemotherapy with PD-1 blockade, achieving superior safety while maintaining non-inferior 3-year failure-free survival; meanwhile efficacy-enhancing employs adjuvant immunotherapy to improve survival specifically in high-risk patients, supporting the transition toward risk-adapted strategies. In radiotherapy, international consensus guidelines recommend reducing target volumes and sparing normal tissues to minimize side effects. For recurrent or metastatic NPC, antibody-drug conjugates(ADCs) and novel immunotherapeutic combinations show promise in overcoming treatment resistance and expanding therapeutic options. Furthermore, advances in artificial intelligence and deeper understanding of resistance mechanisms are accelerating clinical innovation. Collectively, these advances underscore the ongoing shift toward reduced toxicity, improved efficacy, and greater precision in the management of NPC.

Indexed as

antibody–drug conjugateimmunotherapynasopharyngeal carcinomaprecision radiotherapy

Identifiers

PMID42614274
PMCPMC13481315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.