ArticleFrontiers in neurology2026
Admission systemic inflammatory indices and 6-month functional outcome after endovascular thrombectomy for acute ischemic stroke: an exploratory single-center cohort study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Many patients still have poor functional outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke. Systemic inflammatory indices from routine blood tests have been proposed as accessible prognostic biomarkers. We evaluated the association of admission neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with 6-month functional outcome after EVT, and tested whether they provide incremental prognostic value beyond the National Institutes of Health Stroke Scale (NIHSS). Methods: We retrospectively analyzed consecutive patients undergoing EVT for anterior circulation acute ischemic stroke at one center. The primary outcome was poor functional outcome (modified Rankin Scale [mRS] 4-6) at 6 months. Associations were assessed with logistic regression and ROC analysis. Incremental value over NIHSS was assessed with likelihood-ratio tests, AUC comparison (DeLong), reclassification metrics (NRI, IDI), and decision-curve analysis. Results: Of 90 patients, 82 (91.1%) completed follow-up, of whom 40 (48.8%) had poor outcomes; regression used 75 patients with complete inflammatory-index data (35 events). At the univariable level, poor outcome was associated with higher NIHSS (median 15.5 vs. 8.0, Conclusion: Admission NLR, SII, and SIRI are associated with 6-month poor outcome after EVT, but this association is largely explained by stroke severity, with no detectable incremental value beyond NIHSS. These exploratory findings are hypothesis-generating and require prospective multicenter validation before clinical use.
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