Evidence map›Paper›PMID 42614182›Full record

ArticleFrontiers in neurology2026

Cerebellar ataxia-onset ALS with

Denis V Shevchuk, Evgeny P Nuzhnyi, Ekaterina Yu Fedotova, Margarita V Ershova, Ivan V Minaev, Georgy A Anikin, Arina R Protsenko, Natalia Yu Abramycheva, Maria N Zakharova, Sergey N Illarioshkin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Denis V ShevchukRussian Center of Neurology and Neurosciences, Moscow, Russia.
Evgeny P NuzhnyiRussian Center of Neurology and Neurosciences, Moscow, Russia.
Ekaterina Yu FedotovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Margarita V ErshovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Ivan V MinaevRussian Center of Neurology and Neurosciences, Moscow, Russia.
Georgy A AnikinRussian Center of Neurology and Neurosciences, Moscow, Russia.
Arina R ProtsenkoRussian Center of Neurology and Neurosciences, Moscow, Russia.
Natalia Yu AbramychevaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Maria N ZakharovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Sergey N IllarioshkinRussian Center of Neurology and Neurosciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Amyotrophic lateral sclerosis (ALS) associated with mutations in the superoxide dismutase 1 ( Methods: We describe four unrelated patients: three men and one woman, aged 35 to 49 years at symptom onset, who carried the Results: All patients presented with progressive gait ataxia as their initial and predominant symptom, with upper and lower motor neuron signs emerging months to years later and ultimately meeting criteria for ALS. Diagnostic latencies from ataxia onset to recognition of ALS ranged from 3 to 9 years. Cerebellar signs included gait and limb ataxia, dysmetria, intention tremor, and oculomotor abnormalities; neuroimaging revealed mild cerebellar atrophy only in one case, and electrophysiological evidence of lower motor neuron involvement was often limited at initial assessment. To our knowledge, this is the largest reported case series of patients homogeneous for a single Conclusion: The findings expand the clinical spectrum of

Indexed as

Amyotrophic Lateral SclerosisCerebellar AtaxiaSuperoxide Dismutase-1AdultFemaleHumansMaleMiddle AgedMutationPhenotypeSOD1 protein, humanSuperoxide Dismutase-1amyotrophic lateral sclerosisAsp91Alacerebellar ataxiaD91Agenotype–phenotype correlationmotor neuron diseaseSOD1

Identifiers

PMID42614182
PMCPMC13481206

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.