ArticleFrontiers in physiology2026
Transcriptomic analysis revealed the protective role of genistein against oxidized fish oil-induced oxidative stress and inflammatory responses in turbot (
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Extensive investigations have been conducted across mammalian species to explore the redox-modulating and inflammation-resolving properties of genistein and the mechanisms involved; however, research on the functions of this compound in aquatic species stay insufficient. Therefore, the present research was designed to determine whether oxidative liver injury and inflammatory immune reactions in turbot ( Methods: In this study, three dietary treatments were established: a fresh fish oil group (FFO), an oxidized fish oil group (OFO) in which fresh oil was completely replaced by oxidized oil, and a GEN40 group, where 40 mg/kg genistein was supplemented to the OFO basal diet. Juvenile turbot with an initial mean body mass of 10.00 ± 0.03 g were used in this study, and the feeding trial lasted 12 weeks. Results: As revealed by the results, hepatic mitochondrial impairment was induced in turbot by oxidized fish oil ingestion, as reflected by reduced cristae number, cristae disorganization, and concentric cristae formation, while a significant increase in hepatic superoxide anion abundance was also noted ( Discussion: The above results confirmed that adding 40 mg/kg of genistein to an oxidized fish oil-based diet significantly alleviated hepatic oxidative stress and inflammatory injury mediated by the oxidized fish oil; besides
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