ArticleESC heart failure2026
Parity and heart failure risk in diabetic women with coronary artery disease: a multicentre cohort study.
Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionWomen with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) face elevated heart failure (HF) risk compared with men. Although population-based studies have linked parity to cardiovascular outcomes, evidence is limited among women with established cardiovascular disease. We investigated the association between parity and HF hospitalization and mortality in women with T2DM and CAD.
methodsThis multicentre retrospective cohort study enrolled 2314 women with T2DM and CAD from 70 hospitals between 2005 and 2022 in Japan. Participants were stratified by parity and followed for a median of 2297 days. Outcomes included HF hospitalization, all-cause mortality, acute myocardial infarction, and stroke. Cox proportional hazards models adjusted for age, cardiovascular risk factors, and medication use.
resultsWomen with ≥5 births had significantly higher incidences of HF hospitalization (4.90 vs 3.03 per 100 person-years) and mortality (4.85 vs 3.76 per 100 person-years) compared with <5 births. After adjustment, high parity (≥5 births) was significantly associated with HF hospitalization [hazard ratio (HR): 1.41, 95% confidence interval (CI): 1.04-1.90] but not with mortality (HR: 1.22, 95% CI: .92-1.62). No associations were observed with acute myocardial infarction or stroke.
conclusionAmong women with T2DM and CAD, high parity independently and outcome specifically predicted HF hospitalization, regardless of accumulated cardiovascular risk factors. Reproductive history should be considered in HF risk stratification even for high-risk women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.