Evidence map›Paper›PMID 42614003›Full record

ArticleMicrobial biotechnology2026

A Safe and Effective Bivalent Vaccine Candidate Against Duck Enteritis Virus and Duck-Origin Novel Goose Parvovirus.

Liu Chen, Jionggang Hua, Weicheng Ye, Cun Zhang, Xinjin Li, Yinchu Zhu, Yuan Fu, Liang He, Suxin Huo, Zongxiao Wang and 2 more

Abstract read
In one paragraph

Article in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liu ChenZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0002-7973-6533
Jionggang HuaZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0000-8174-0622
Weicheng YeZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0009-1336-232X
Cun ZhangZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0002-0629-1262
Xinjin LiZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0005-6593-7819
Yinchu ZhuZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0003-0223-1331
Yuan FuZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0002-0167-642X
Liang HeZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0004-6043-0712
Suxin HuoZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0002-8479-388X
Zongxiao WangZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0002-6952-0015
Zhuanli WuZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0009-0003-5645-1492
Tao YunZhejiang Key Laboratory of Livestock and Poultry Biotech Breeding, Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.ORCID https://orcid.org/0000-0002-0804-2526

Funding

the National Natural Science Foundation of China 32473008the Zhejiang Provincial Natural Science Foundation of China LGN22C010005
6 · The paper itself

Abstract

Since 2015, duck-origin novel goose parvovirus (NGPV) has caused severe economic losses to the Chinese duck industry, with no licensed vaccines or treatments available. Our previous study constructed a recombinant duck enteritis virus (rDEV) from an attenuated vaccine strain, which conferred full protection against virulent DEV challenge. NGPV VP2 is the major immunogenic structural antigen. In this study, we generated a recombinant virus rNGPV VP2-Cre by inserting the NGPV VP2 gene into the rDEV genome. VP2 expression and virus-like particle assembly were confirmed. Safety and efficacy were evaluated in ducklings. The results showed that rNGPV VP2-Cre was safe, facilitated clearance of NGPV and provided strong protection against challenge with a highly virulent DEV strain. In summary, rNGPV VP2-Cre represents a promising bivalent vaccine candidate for concurrent control of DEV and NGPV infections.

Indexed as

Parvoviridae InfectionsParvovirinaeParvovirusPoultry DiseasesViral VaccinesAnimalsAntibodies, ViralDucksVaccines, SyntheticVaccines, Virus-Like ParticleAntibodies, ViralVaccines, SyntheticVaccines, Virus-Like ParticleViral Vaccinesbivalent vaccineduck enteritis virusduck origin‐novel goose parvovirusimmunoprotectionvirus‐like particles

Identifiers

PMID42614003
PMCPMC13487463

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.