Evidence map›Paper›PMID 42613972›Full record

ArticleClinical and translational medicine2026

Precision post-translational modification of PML defines neuroblastoma clinical behaviour.

Sreenidhi Mohanvelu, Poorvi Subramanian, Sheeja Aravindan, Madhi Oli Ramamurthy, Sivaroopan Aravindan, Afsana Parveen Jahir Hussain, Natarajan Aravindan

Abstract read
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In one paragraph

Article in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sreenidhi MohanveluDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.
Poorvi SubramanianDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0001-9604-0397
Sheeja AravindanOU-Health Stephenson Cancer Center, Oklahoma City, Oklahoma, USA.
Madhi Oli RamamurthyDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.
Sivaroopan AravindanDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.
Afsana Parveen Jahir HussainDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0009-0009-7378-2975
Natarajan AravindanDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, USA.ORCID 0000-0001-9150-3911

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
Mentoring Translational Cancer Research in OklahomaP30GM154635 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Rajagopal Ramesh · 2024 to 2026
$4.3M
Department of Defense CA-210339Kerr Foundation Funding 28-34200National Cancer Institute Cancer Center Support Grant P30CA225520NCI NIH HHS P30 CA225520NIGMS NIH HHS P30 GM154635NIH HHS P30GM154635Oklahoma Center for the Advancement of Science and Technology OCAST-HR19-045Oklahoma Tobacco Settlement Endowment Trust R23-03
6 · The paper itself

Abstract

backgroundPromyelocytic leukaemia protein (PML), a key regulator of nuclear architecture and cellular homeostasis, is increasingly recognised for its tumour-suppressive functions. In neuroblastoma (NBL), a clinically heterogeneous and aggressive paediatric malignancy, the prognostic role of PML and its post-translational modifications remains largely unexplored.

methodsWe investigated the prognostic and predictive significance of PML expression and its site-specific phosphorylation at serine 518 (S

resultsOur findings reveal a striking inverse relationship between PML abundance and S

conclusionPML loss and site-specific phosphorylation of PML at S KEY POINTS: PML depletion is a defining feature of aggressive neuroblastoma and is associated with advanced stage, metastasis and relapse. S

Indexed as

NeuroblastomaPromyelocytic Leukemia ProteinProtein Processing, Post-TranslationalFemaleHumansMalePhosphorylationPrognosisPML protein, humanPromyelocytic Leukemia Proteinhigh‐risk neuroblastomaphosphorylationPMLpost‐translational modificationspPMLpromyelocytic leukaemia proteinspatiotemporal expression

Identifiers

PMID42613972
PMCPMC13487384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.