Evidence map›Paper›PMID 42613919›Full record

ArticleExperimental physiology2026

The contributions of nocturnal hypoxaemia and sleep disturbances to acute mountain sickness.

D M Williamson, M K Gudelunas, J W Sall

Abstract read
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In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

D M WilliamsonDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-3791-3682
M K GudelunasDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA.
J W SallDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA.

Funding

The primary clinical trial was funded by Tasly Pharmaceuticals, whereas this sub-study was supported by a seed grant from the UCSF Department of Anesthesia.
6 · The paper itself

Abstract

Acute mountain sickness (AMS) is common after ascent to altitude, yet individual susceptibility remains difficult to predict and diagnosis relies on subjective report. Sleep disturbances and nocturnal hypoxaemia at altitude may provide insight, but their relationship to AMS is incompletely understood. In a sub-study of a randomized, placebo-controlled trial, 112 healthy, lowland-dwelling volunteers rapidly ascended to 3810 m. AMS was assessed using the 2018 Lake Louise Scoring System (LLSS); sleep scores were recorded separately. Overnight monitoring used the WatchPAT300 device to measure oxygen saturation, oxygen desaturation index, respiratory disturbance index, apnoea-hypopnoea index and inferred sleep stage. Thirty-eight participants (34%) developed AMS by the 2018 LLSS criteria. Compared with unaffected individuals, those with AMS had lower mean nocturnal

Indexed as

acclimatizationacute mountain sicknessLake Louise Scoring Systemovernight oximetrysleep architecturesleep‐disordered breathingsleep oximetry

Identifiers

PMID42613919
PMCPMC13487406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.