Caenorhabditis elegans as a Model Host for Fusobacterium nucleatum.

Suhani B Bhakta, Yi-Wei Chen

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Suhani B BhaktaMolecular Biology Institute, University of California - Los Angeles, Los Angeles, CA, USA.

Yi-Wei ChenDivision of Oral & Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA. yiweichen515@g.ucla.edu.ORCID https://orcid.org/0000-0001-7746-6026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fusobacterium nucleatum is a Gram-negative bacterium that plays a central role in biofilm formation within the oral cavity. While traditionally considered a commensal organism, accumulating evidence has implicated F. nucleatum in the pathogenesis of a range of oral and systemic diseases, including various cancers, inflammatory bowel disease, and adverse pregnancy outcomes such as preterm birth. Despite its emerging recognition as a pathobiont, relatively few virulence factors have been characterized. In this study, we present Caenorhabditis elegans as a versatile and tractable model for investigating F. nucleatum virulence. We detail protocols for synchronizing C. elegans populations, assessing nematode survival postinfection, and quantifying worm motility to evaluate the physiological impact of infection. These methodologies enable high-throughput screening of F. nucleatum virulence determinants and offer a valuable platform for advancing our understanding of its pathogenic potential.

Indexed as

Caenorhabditis elegansFusobacterium InfectionsFusobacterium nucleatumHost-Pathogen InteractionsAnimalsDisease Models, AnimalVirulenceVirulence FactorsVirulence FactorsCaenorhabditis elegansFusobacterium nucleatumMotilityPathogenesisSurvival

Identifiers

PMID42613578

DOI10.1002/cpmc.109

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.