Modeling Fusobacterium nucleatum-Driven Colorectal Cancer in Apc-Mutant Mice.

Bing Han, Wei Liu, Yimin Chen, Yi-Wei Chen, Hung Ton-That, Jia Chang, Cun-Yu Wang

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bing HanDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.

Wei LiuDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.

Yimin ChenDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.

Yi-Wei ChenDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-7746-6026

Hung Ton-ThatDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-1611-0469

Jia ChangDivision of Regenerative and Reconstructive Science, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA. jiachang@dentistry.ucla.edu.

Cun-Yu WangDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA. cunywang@ucla.edu.

Funding

Assembly and function of outer membrane tubules in Fusobacterium nucleatumR01DE033900 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hung Ton-That · 2024 to 2026

$1.4M

NIDCR NIH HHS R01 DE033900

6 · The paper itself

Abstract

Colorectal cancer (CRC) typically initiates with mutations in the adenomatous polyposis coli (Apc) gene, followed by the influence of environmental factors. Among these, Fusobacterium nucleatum has emerged as an important CRC-enriched microbial species with demonstrated tumor-promoting potential. To investigate the contribution of F. nucleatum in the context of oncogenic mutations, physiologically relevant mouse models are essential. While Apc

Indexed as

Adenomatous Polyposis Coli ProteinColorectal NeoplasmsFusobacterium InfectionsFusobacterium nucleatumAnimalsDisease Models, AnimalHumansMiceMutationAdenomatous Polyposis Coli ProteinApcColorectal cancerFISHFusobacterium nucleatumMouse models

Identifiers

PMID42613577

DOI10.1016/j.mib.2014.11.013

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.