Evidence map›Paper›PMID 42613575›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

A Mouse Model for Fusobacterium nucleatum-Mediated Experimental Periodontitis.

Sharon Kim, Chungyu Chang, Hung Ton-That, No-Hee Park, Reuben H Kim

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharon KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, Section of Restorative Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA.
Chungyu ChangDivision of Oral & Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.
Hung Ton-ThatDivision of Oral & Systemic Health Sciences, School of Dentistry, University of California - Los Angeles, Los Angeles, CA, USA.
No-Hee ParkThe Shapiro Family Laboratory of Viral Oncology and Aging Research, Section of Restorative Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA.
Reuben H KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, Section of Restorative Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA. rkim@dentistry.ucla.edu.

Funding

Molecular Assembly on the Cell Surface of ActinomycesR01DE017382 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hung Ton-That · 2008 to 2026
$6.7M
NIDCR NIH HHS R01 DE017382
6 · The paper itself

Abstract

Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium that naturally colonizes the human oral cavity and is recognized as an etiological agent in both local and systemic diseases, including periodontitis, preterm birth, and colorectal cancer. To advance research into the systemic impact of oral-origin F. nucleatum-associated pathologies, it is crucial to optimize the use of animal models. In this study, we present a detailed protocol for establishing a mouse model of experimental periodontitis through oral inoculation of bacteria, including F. nucleatum. This model provides a valuable platform for investigating the pathogenic mechanisms and systemic consequences of oral bacterial infections.

Indexed as

Fusobacterium InfectionsFusobacterium nucleatumPeriodontitisAnimalsDisease Models, AnimalMiceAlveolar bone lossFusobacterium nucleatumLigatureMouse model

Identifiers

PMID42613575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.