ArticleIntensive care medicine experimental2026
Intravenous anti-P. aeruginosa IgY antibodies increase bacterial concentration in porcine septic shock with bacteremia.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBacteremia caused by Pseudomonas aeruginosa carries a high mortality rate. P. aeruginosa also possesses several resistance mechanisms to antibiotics, mandating studies of novel therapies. Specific polyclonal anti-P. aeruginosa IgY-antibodies (Pa-IgY) have been reported to decrease P. aeruginosa concentration in the airways. In this study, we investigated the effects of intravenous Pa-IgY on P. aeruginosa septic shock.
methodPigs were anaesthetized, mechanically ventilated, and allocated to receive either intravenous P. aeruginosa only, P. aeruginosa + low dose Pa-IgY, P. aeruginosa + high dose Pa-IgY or high dose Pa-IgY only. The experiment lasted 6 h with repeated blood cultures, blood tests, monitoring of physiological parameters and postmortem organ cultures. We performed in vitro cultures of P. aeruginosa +/- porcine neutrophils and +/- Pa-IgY and flow cytometry of FITC-marked inactivated P. aeruginosa cultured with porcine blood +/- Pa-IgY.
resultsThe pigs developed septic shock with accompanying respiratory failure as a result of the P. aeruginosa infusion. Treatment with Pa-IgY increased bacterial concentrations, both in the porcine model in blood (p = 0.004) and when P. aeruginosa was cultured after pre-treatment with Pa-IgY +/- neutrophils in vitro (p < 0.001). The phagocytosis of P. aeruginosa in porcine blood was similar with and without Pa-IgY. Pa-IgY had no effect on the development or severity of septic shock. Animals with high dose Pa-IgY had higher PaO
conclusionIn pigs with P. aeruginosa septic shock, treatment with Pa-IgY was associated with higher bacterial concentration in blood without an increased inflammatory response.
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