Evidence map›Paper›PMID 42613544›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Gangliosides in Neural Stem Cell Fate Determination and Nerve Cell Specification: Preparation and Administration.

Yutaka Itokazu, Toshio Ariga, Takahiro Fuchigami, Dongpei Li

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Sphingolipids in Emotional Well-Being.Journal of neurochemistry · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yutaka Itokazu *Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA, USA. yitokazu@augusta.edu.ORCID http://orcid.org/0000-0001-7800-8262
Toshio Ariga *Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Takahiro FuchigamiDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Dongpei LiDepartment of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gangliosides are sialylated glycosphingolipids with essential yet enigmatic functions in both healthy and disease brains. Among them, GD3 represents the predominant glycosphingolipid species in neural stem cells (NSCs), comprising over 80% of the total. On the other hand, the expression of GM1 is upregulated through a GM1-modulated epigenetic gene regulation mechanism involving GM2 synthase. GM1, in turn, influences the transcriptional activity of neuronal genes to maintain neuronal functions. To elucidate the functional roles of gangliosides, we introduce methods to isolate GD3 and GM1 and administer them into the mouse brain to investigate their functions on NSC fate determination and nerve cell specification.

Indexed as

GangliosidesG(M1) GangliosideNeural Stem CellsNeuronsAnimalsBrainCell DifferentiationMiceNeurogenesisganglioside, GD3GangliosidesG(M1) GangliosideCarbohydrateGangliosideGanglioside purificationGD3GM1Lipid membraneMicrodomainNeural stem cellNeurogenesisRegeneration

Identifiers

PMID42613544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.