Evidence map›Paper›PMID 42613528›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Expression of Mono- and Dimeric Ganglioside-Binding Lectins and Their Cellular Functions.

Kenichi Kamata, Marco Gerdol, Imtiaj Hasan, Sultana Rajia, S M Abe Kawsar, Tatsuya Kawasaki, Masao Yamada, Yukiko Ogawa, Yasuhiro Ozeki, Hideaki Fujita and 1 more

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kenichi KamataDepartment of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan.
Marco GerdolDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Imtiaj HasanDepartment of Microbiology, Faculty of Biological Science, University of Rajshahi, Rajshahi, Bangladesh.
Sultana RajiaCenter for Interdisciplinary Research, Varendra University, Rajshahi, Bangladesh.
S M Abe KawsarDepartment of Chemistry, Faculty of Science, University of Chittagong, Chittagong, Bangladesh.
Tatsuya KawasakiGraduate School of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan.
Masao YamadaGraduate School of NanoBio Sciences, Yokohama City University, Yokohama, Japan.
Yukiko OgawaGraduate School of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan.
Yasuhiro OzekiGraduate School of NanoBio Sciences, Yokohama City University, Yokohama, Japan.
Hideaki FujitaGraduate School of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan.
Yuki FujiiGraduate School of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan. yfujii@niu.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the 2020s, a novel R-type lectin family with β-trefoil folding was found in Mytilidae (phylum Mollusca). SeviL, as described in this chapter, is the lectin discovered from Mytilisepta virgata, which is habituated in the intertidal community in the northwestern Pacific Ocean. SeviL is bound to the glycan moiety of gangliosides such as asialo-GM1 (GA1: Galβ1-3GalNAcβ1-4Galβ1-4Glc), GM1b (Neu5Acα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glc), and SSEA-4 (Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ1), leading to apoptosis of cancer cells and M1 macrophage polarization. We describe how to prepare dimeric and monomeric SeviLs, which are valuable in studying the function of gangliosides in terms of glycan recognition. It also introduces how to apply lectins to ganglioside studies on concentration-dependent growth inhibition and cell differentiation.

Indexed as

GangliosidesLectinsAnimalsApoptosisCell DifferentiationHumansGangliosidesLectinsApoptosisDifferentiationGangliosidesMAPK FamilyMytilidaeR-type LectinSeviLSignal Transduction

Identifiers

PMID42613528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.