ReviewNature immunology2026
Hallmarks of the multidimensional immune response to trauma in humans.
Review in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Trauma disrupts the structure-function interplay of life, instantly engaging innate and adaptive immunity together with neuroendocrine, endovascular and metabolic axes. The immune response emerges from disturbances in overarching hallmarks of any living being-barrier systems, molecular communication and adaptation-further shaped by patient-specific, injury-specific and modern care-specific determinants. These factors drive adaptive or maladaptive immune trajectories, from restitution to chronic dysfunction or death. Multi-omics analyses of trauma cohorts now enable endotype discovery, providing a framework for mechanism-guided, spatiotemporal precision immunomodulation. This Review focuses exclusively on human studies to conceptualize major themes in clinical trauma immunology to guide future research.
Indexed as
Identifiers
42613462What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.