Evidence map›Paper›PMID 42613417›Full record

ArticleMolecular psychiatry2026

Cross-species brain-wide mapping reveals convergent mesocorticolimbic engagement by nucleus accumbens deep brain stimulation.

Austin Y Feng, Daniel A N Barbosa, Austen B Casey, Daniel Ryskamp Rijsketic, Juliana S Salgado, Harvey Huang, Robert C Malenka, Dora Hermes, Kai J Miller, Casey H Halpern and 1 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Austin Y Feng *Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Daniel A N Barbosa *Department of Neurosurgery, Pennsylvania Hospital, Perelman School of Medicine, Richards Medical Research Laboratories, University of Pennsylvania, Philadelphia, PA, USA.
Austen B CaseyDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4670-851X
Daniel Ryskamp RijsketicDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2197-0730
Juliana S SalgadoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3687-846X
Harvey HuangMedical Scientist Training Program, Mayo Clinic, Rochester, MN, USA.
Robert C MalenkaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5428-5211
Dora HermesDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-8683-8909
Kai J MillerDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Casey H HalpernDepartment of Neurosurgery, Pennsylvania Hospital, Perelman School of Medicine, Richards Medical Research Laboratories, University of Pennsylvania, Philadelphia, PA, USA. casey.halpern@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-3907-216X
Boris D HeifetsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA. bheifets@stanford.edu.ORCID http://orcid.org/0000-0003-1474-0379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleus accumbens (NAc) deep brain stimulation (DBS) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. Uncovering the accumbens network that is engaged by DBS is a critical step forward in understanding how modulating this important node impacts the broader mesocorticolimbic circuit. Using whole-brain clearing and unbiased, brain-wide neural activity mapping, we found that NAc DBS increases neural activity in a coordinated mesocorticolimbic network in mice. Simultaneous intracranial electrophysiology recordings from the human NAc and brief stimulation epochs of analogous mesocorticolimbic nodes revealed patterns of connectivity between these regions and the NAc. Altogether, these results link brain-wide network mapping in mice with a hypothesis-driven test of human NAc connectivity, consistent with a coordinated mesocorticolimbic network that may be relevant to the mechanisms of NAc DBS.

Identifiers

PMID42613417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.