Evidence map›Paper›PMID 42613390›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Nutritional outcomes associated with enteral versus parenteral nutritional support during intensive induction chemotherapy for acute myeloid leukemia.

Marianne Schwarz, Anne Lebreton, Marie-Antoinette Lester, Tony Marchand, Roch Houot, Aurélien Giltat, Chama Mokeddem, Jean Baptiste Mear, Elise Darras, Corentin Orvain and 2 more

Abstract readObservational StudyComparative StudyMulticenter Study
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In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marianne SchwarzService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France.
Anne LebretonPharmacie Hospitalière, CHU d'Angers, Angers, France.
Marie-Antoinette LesterPharmacie Hospitalière, CHU Rennes, Rennes, France.
Tony MarchandService d'Hématologie Clinique, FHU GOAL, CHU Rennes, Rennes, France.
Roch HouotService d'Hématologie Clinique, FHU GOAL, CHU Rennes, Rennes, France.
Aurélien GiltatService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France.
Chama MokeddemService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France.
Jean Baptiste MearService d'Hématologie Clinique, FHU GOAL, CHU Rennes, Rennes, France.
Elise DarrasService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France.
Corentin OrvainService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France.
Mathilde HunaultService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France.
Aline Tanguy-SchmidtService Des Maladies du Sang, FHU GOAL, CHU d'Angers, Angers, France. AlSchmidt@chu-angers.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDuring acute myeloid leukemia (AML) intensive chemotherapy induction, nutrition is an important part of supportive care and may influence treatment tolerance and clinical outcomes, impacting patient prognosis. Several nutritional supports can be used to limit malnutrition, but limited data are available to guide the choice of nutritional support. This study aimed to compare nutritional outcomes associated with enteral nutrition (EN) and parenteral nutrition (PN) during intensive induction chemotherapy for AML in a real-world retrospective setting.

methodsA retrospective observational study was conducted in two French academic centers (Angers University Hospital and Rennes University Hospital), including all adult patients with AML receiving intensive induction chemotherapy.

resultsBetween January 2017 and March 2022, 327 patients were included, with a median age of 60 years (range 18-81). Among these patients, 265 (81%) patients received nutritional support during induction therapy: enteral nutrition (EN) for 135 patients and parenteral nutrition (PN) for 130 patients. Patients who received EN had better nutritional status at the end of induction therapy with lower weight loss (5% vs. 6.7%, P = 0.012), higher albumin levels (32 vs. 27.9, P < 0.001), and less severe nutritional index (NRI; 24% vs. 57%, P < 0.001) compared to the PN group. However, no significant difference was observed in overall survival between the two groups.

conclusionIn this retrospective comparison of two institutional nutritional support strategies, patients initially managed with EN experienced lower weight loss and lower rates of severe malnutrition at the end of induction therapy.

Indexed as

Enteral NutritionInduction ChemotherapyLeukemia, Myeloid, AcuteParenteral NutritionAdolescentAdultAgedAged, 80 and overFemaleFranceHumansMaleMalnutritionMiddle AgedNutritional StatusRetrospective StudiesAcute myeloid leukemiaEnteral nutritionInduction therapyNutritional statusParenteral nutritionWeight loss

Identifiers

PMID42613390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.