Evidence map›Paper›PMID 42613377›Full record

ArticleNature cancer2026

A lactate-α-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells accelerates tumor progression by inducing NK cell senescence.

Tiezhu Shi, Yufeng Ding, Ying Chen, Xiangyin Tan, Fangfang Qu, Dongwei Xu, Xinyu Liu, Yixue Li, Yan-Fang Liu, Xiaolin Zhang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tiezhu Shi *Department of Pathology, Changhai Hospital, Naval Medical University, Shanghai, China.
Yufeng Ding *School of Life Sciences, Guangzhou University, Guangzhou, China.
Ying Chen *Department of Gastroenterology, Changhai Hospital affiliated to the Naval Medical University, Shanghai, China.
Xiangyin Tan *Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.ORCID http://orcid.org/0009-0002-0418-6853
Fangfang Qu *Guangzhou National Laboratory, No. 9 XingDaoHuanBei Road, Guangzhou International Bio Island, Guangzhou, China.
Dongwei XuDepartment of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-9802-0664
Xinyu LiuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yixue LiGuangzhou National Laboratory, No. 9 XingDaoHuanBei Road, Guangzhou International Bio Island, Guangzhou, China.
Yan-Fang LiuDepartment of Pathology, Changhai Hospital, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-2923-0729
Xiaolin ZhangAllergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Guanzhen YuAllergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. qiaoshanqian@aliyun.com.ORCID http://orcid.org/0000-0001-6193-8148
Jialiang ShaoDepartment of Urology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. jialiang.shao1@shgh.cn.ORCID http://orcid.org/0009-0007-5695-6377
Xiongjun WangDepartment of Pathology, Changhai Hospital, Naval Medical University, Shanghai, China. wangxiongjun@gzhu.edu.cn.ORCID http://orcid.org/0009-0006-8167-9415

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82272174
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

Cellular SenescenceKetoglutaric AcidsKiller Cells, NaturalLactic AcidLymphocytes, Tumor-InfiltratingNeoplasmsT-Lymphocytes, RegulatoryAnimalsCell Line, TumorDisease ProgressionGlutamate DehydrogenaseHumansMiceTumor MicroenvironmentGlutamate DehydrogenaseKetoglutaric AcidsLactic Acid

Identifiers

PMID42613377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.