Evidence map›Paper›PMID 42613338›Full record

ArticleScientific reports2026

Comparing traditional and NGS-based screening strategies for thalassemia in a high-prevalence Hakka population: a population-based study.

Haimei Qi, Liqiong Wu, Jie Wang, Jian Xiao, Yulian Zhou, Shilian Chen, Xianping Yuan, Xiaoying Liu, Zhuling Zhang, Haijun Chen and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

15 authors.

Haimei QiDepartment of Clinical Laboratory, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
Liqiong WuDepartment of Health Examination, Xingguo County Maternal and Child Health Hospital, Ganzhou, China.
Jie WangDepartment of Clinical Laboratory, Nankang District Maternal and Child Health Hospital, Ganzhou, China.
Jian XiaoHealth Care Department, Xinfeng County Maternal and Child Health Hospital, Ganzhou, China.
Yulian ZhouDepartment of Clinical Laboratory, Dayu County Maternal and Child Health Hospital, Ganzhou, China.
Shilian ChenDepartment of Clinical Laboratory, Xunwu County Maternal and Child Health Hospital, Ganzhou, China.
Xianping YuanDepartment of Obstetrics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
Xiaoying LiuDepartment of Health Examination, Xingguo County Maternal and Child Health Hospital, Ganzhou, China.
Zhuling ZhangDepartment of Obstetrics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
Haijun ChenDepartment of Medical Genetics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
Lin XiaoDepartment of Medical Genetics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
JunKun ChenDepartment of Medical Genetics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
Wenzhong LiDepartment of Clinical Laboratory, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China.
Shichun ShenDepartment of Medical Genetics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, China. chinesuzg@163.com.
Liyun SongDepartment of Clinical Laboratory, Ganzhou People's Hospital, Ganzhou, China. chinesu@126.com.

Funding

Health Commission Program of Ganzhou GZWJW202502388Health Commission Program of Jiangxi 202410831
6 · The paper itself

Abstract

Thalassemia is one of the most common monogenic disorders in southern China, with the Hakka population exhibiting a distinct genetic profile. This study evaluated whether next-generation sequencing (NGS)-based universal screening offers advantages over traditional cascade screening in this specific population. We enrolled 91,857 reproductive-age individuals in Ganzhou, a high-prevalence Hakka region, comparing 37,500 participants who underwent traditional screening (2019-2021) with 54,357 who received NGS-based screening. NGS-based screening detected thalassemia carriers at a rate 4.74 times higher than traditional screening (15.05% vs. 3.18%), particularly identifying silent α-thalassemia and β

Indexed as

alpha-Thalassemiabeta-ThalassemiaGenetic TestingHigh-Throughput Nucleotide SequencingThalassemiaAdultChinaFemaleHumansMaleMass ScreeningPrevalenceCarrier screeningCost-effectivenessHakka populationNext-generation sequencingThalassemia

Identifiers

PMID42613338
PMCPMC13486634

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