Evidence map›Paper›PMID 42613320›Full record

ArticleInternational journal of oral science2026

Roles of integrin β1 and discoidin domain receptor 2 in cranial regeneration and skeletal progenitor cell function.

Yuanyuan Han, Chunxi Ge, Rajay A Kamath, Vesa Kaartinen, Renny T Franceschi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oral science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanyuan HanDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6006-9825
Chunxi GeDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7719-1077
Rajay A KamathDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Vesa KaartinenDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, MI, USA.
Renny T FranceschiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA. rennyf@umich.edu.ORCID http://orcid.org/0000-0003-1405-2541

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Discoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone FormationR01DE029465 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2021 to 2025
$2.4M
NIAMS NIH HHS P30 AR069620NIDCR NIH HHS R01 DE029465U.S. Department of Defense (United States Department of Defense) CDMRP W81XWH-20-1-0571U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) P30 AR069620U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE029465
6 · The paper itself

Abstract

The two principal collagen receptors in bone, the collagen-binding β1 integrins and discoidin domain receptor 2 (DDR2), each have important roles in development, but their functions in bone regeneration are largely unexplored. Using a critical-size calvarial defect model, we assessed the relative roles of these two receptor classes in BMP2-induced regeneration using a conditional knockout approach where Itgb1 (encodes integrin β1) and/or Ddr2 were selectively inactivated in GLI1

Indexed as

Bone RegenerationIntegrin beta1Receptor Protein-Tyrosine KinasesReceptors, MitogenSkullStem CellsAnimalsBone Morphogenetic Protein 2Cell DifferentiationCell MovementCell ProliferationDiscoidin Domain Receptor 2MiceMice, KnockoutOsteoblastsOsteogenesisBone Morphogenetic Protein 2Discoidin Domain Receptor 2Integrin beta1Itgb1 protein, mouseReceptor Protein-Tyrosine KinasesReceptors, Mitogen

Identifiers

PMID42613320
PMCPMC13486828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.