Evidence map›Paper›PMID 42613051›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Acute exposure to cell-free mitochondrial DNA induces pregnancy-specific aortic endothelial dysfunction and organ-selective inflammation in rats.

Nataliia Hula, Reneé de Nazaré Oliveira da Silva, Desirae Escalera, Leslie Lopez, Gabrielle Kelly, Isabelle K Gorham, Megan Rowe, Taiming Liu, Arlin B Blood, Eugenia Mata-Greenwood and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Nataliia HulaDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.ORCID 0000-0002-4923-6589
Reneé de Nazaré Oliveira da SilvaDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.
Desirae EscaleraDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.
Leslie LopezDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.
Gabrielle KellyDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.
Isabelle K GorhamDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Megan RoweDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-5962-1229
Taiming LiuDivision of Neonatology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, United States.
Arlin B BloodDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.ORCID 0000-0002-4803-5021
Eugenia Mata-GreenwoodDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.
Xiang-Qun HuDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.ORCID 0000-0003-1626-9541
Lubo ZhangDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.
Nicole R PhillipsDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Styliani GoulopoulouDepartment of Basic Sciences, Lawrence D. Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California, United States.ORCID 0000-0001-7636-8256

Funding

Preeclampsia and pre-clinical stages of maternal vascular dementiaR01HL146562 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI GOULOPOULOU, STYLIANI · 2020 to 2024
$2.9M
American Heart Association (AHA) 24POST1198395American Heart Association (AHA) 24POST-1198627HHS | NIH | NHLBI | Division of Intramural Research (DIR) R01 HL146562Loma Linda University (LLU) Dean's Scholarship
6 · The paper itself

Abstract

Pregnancy complications such as preeclampsia are associated with circulating cell-free mitochondrial DNA (mtDNA), a damage-associated molecular pattern capable of activating Toll-like receptor 9 (TLR9). We hypothesized that acute mtDNA exposure induces maternal inflammation and endothelial dysfunction during pregnancy via TLR9 activation. Nonpregnant and pregnant rats (

Indexed as

AortaCell-Free Nucleic AcidsDNA, MitochondrialEndothelium, VascularInflammationVasodilationAcetylcholineAnimalsCytokinesFemaleLiverLungNitric Oxide Synthase Type IIIPregnancyRatsRats, Sprague-DawleyAcetylcholineCell-Free Nucleic AcidsCytokinesDNA, MitochondrialNitric Oxide Synthase Type IIINos3 protein, ratReactive Oxygen SpeciesTlr9 protein, ratToll-Like Receptor 9endothelial dysfunctioninflammationmitochondrial DNApreeclampsiatoll-like receptor 9

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.