Evidence map›Paper›PMID 42612462›Full record

ArticleChild abuse & neglect2026

Infant, maternal and pregnancy associated risk factors for offspring fractures during infancy - A population-based study.

Chris Derauf, Rasika Rao, Katherine King, Roland Hentz, D Dean Potter, Alan R Katz, John Melville

Abstract read
In one paragraph

Article in Child abuse & neglect, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chris DeraufDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States of America. Electronic address: derauf.donald@mayo.edu.
Rasika RaoUniversity of Washington School of Medicine, 4800 Sand Point Way NE, M/S OC.7.830, Seattle, WA, 98105-3901, United States of America. Electronic address: rasika.rao@seattlechildrens.org.
Katherine KingKern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States of America. Electronic address: king.katherine@mayo.edu.
Roland HentzDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States of America. Electronic address: hentz.roland@mayo.edu.
D Dean PotterDivision of Pediatric Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55901, United States of America. Electronic address: potter.d@mayo.edu.
Alan R KatzDepartment of Public Health Sciences, Thompson School of Social Work & Public Health, University of Hawaii, 1960 East-West Rd, Honolulu, HI, 96822, United States of America. Electronic address: katz@hawaii.edu.
John MelvilleDepartment of Pediatrics, University of South Carolina School of Medicine, 6311 Garners Ferry Rd, Columbia, SC, 29209, United States of America. Electronic address: john.melville@uscmed.sc.edu.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NCATS NIH HHS UL1 TR002377NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

backgroundThe etiology of fractures during infancy includes birth trauma, accidents, and uncommon medical conditions predisposing to bone fragility. A 2018 study from Sweden suggested several hypothesized metabolic bone disease (MBD) risk factors elevated maternal BMI, smoking, multiple gestation birth, and small-for-gestational age may predispose infants to fractures.

objectiveTo evaluate the incidence, etiology, and associated infant and maternal factors for non-birth-related fractures during infancy. PARTICIPANTS AND

settingInfants born between 2009 and 2018 in Olmsted County, Minnesota.

methodsThis was a retrospective population-based case-control study. Infants with fractures (n = 89) were matched with controls (n = 162) on birth year, season, and sex. Chart reviews captured demographics, clinical variables, fracture characteristics, and potential MBD risk factors. Conditional logistic regression and Fisher's Exact Tests were used to evaluate associations.

resultsFracture incidence during infancy was 3.9 per 1000. Mean age at fracture was 7.0 months (SD 3.7), with 64% occurring after 6 months of age or more. Accidents were reported in 78% of cases, primarily falls (81%). Reports to child protective services occurred in 30% of cases, with 6.7% showing substantial additional evidence of inflicted injury. Prematurity (<37 weeks) was the only variable associated with fracture risk (OR 2.7; 95% CI 1.03-7.0).

conclusionsNon-birth-related fractures in infancy are uncommon, predominantly accidental, and associated with prematurity. No association was found between infant fracture and several novel hypothesized MBD risk factors. Accurate identification of fracture etiology requires thorough clinical evaluation, as administrative coding alone is insufficient.

Indexed as

Fractures, BoneAdultCase-Control StudiesFemaleHumansIncidenceInfantInfant, NewbornMaleMinnesotaPregnancyRetrospective StudiesRisk FactorsBone diseases - metabolicChild abuseFracturesInfantPregnancyRisk factors

Identifiers

PMID42612462
PMCPMC13543866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.