Evidence map›Paper›PMID 42612334›Full record

ArticleDrug and alcohol dependence2026

Preliminary evaluation of UP2UTeacher, a brief intervention addressing tobacco and nicotine use for high school students.

Melissa A Little, Asal Pilehvari, Indika Mallawaarachchi, Alyssa J Price, Kieland Chandler, Abigail G Wester, Kara P Wiseman

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melissa A LittleUniversity of Virginia, School of Medicine, Department of Public Health Sciences, Charlottesville, VA, USA; University of Virginia, Comprehensive Cancer Center, Charlottesville, VA, USA. Electronic address: mal7uj@virginia.edu.
Asal PilehvariUniversity of Virginia, School of Medicine, Department of Public Health Sciences, Charlottesville, VA, USA; University of Virginia, Comprehensive Cancer Center, Charlottesville, VA, USA.
Indika MallawaarachchiUniversity of Virginia, School of Medicine, Department of Public Health Sciences, Charlottesville, VA, USA.
Alyssa J PriceUniversity of Virginia, School of Medicine, Department of Public Health Sciences, Charlottesville, VA, USA.
Kieland ChandlerUniversity of Virginia, School of Medicine, Department of Public Health Sciences, Charlottesville, VA, USA.
Abigail G WesterUniversity of Illinois Chicago, School of Public Health, Division of Community Health Sciences, Chicago, IL, USA.
Kara P WisemanUniversity of Virginia, School of Medicine, Department of Public Health Sciences, Charlottesville, VA, USA; University of Virginia, Comprehensive Cancer Center, Charlottesville, VA, USA.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NCI NIH HHS P30 CA044579
6 · The paper itself

Abstract

backgroundGiven the changing tobacco landscape and rates of tobacco and nicotine product (TNP) use among youth, there is a need for effective interventions that address all forms of currently available TNPs. The current study sought to evaluate the short-term impact of UP2U Teacher, a single session, universal group-based intervention delivered in schools that addresses all TNPs.

methodsHigh school students (N = 242) were provided with a pre- and immediate post-survey upon receiving UP2UTeacher. McNemar's test was used to assess pre-post changes in willingness among groups. Fixed-effects linear probability models estimated associations between intervention and product-specific perceived harm and addictiveness overall and by group.

resultsAlmost half of the students with a willingness to use TNPs and 28.2% of students who use TNPs transitioned to non-willing following the intervention (p's < 0.01). The intervention was also associated with increases in perceived harm and addictiveness across multiple products. In the overall sample, students reported higher post-intervention perceptions of harm for several products, including nicotine pouches, dissolvables, vaping, cigarillos, cigars, and hookah. Perceived addictiveness increased significantly for all products in the full sample. Stratified analyses showed that students with a willingness to use TNPs experienced the broadest changes in perceived harm and addictiveness, whereas students without a willingness to use TNPs exhibited minimal change in perceived harm and students who use TNPs showed selective increases. Sensitivity analyses yielded similar patterns, supporting the robustness of the findings.

conclusionUP2UTeacher showed promise in reducing adolescents' willingness to use TNPs, suggesting it is a promising school-based TNP intervention. IMPLICATIONS: UP2UTeacher, a brief, single session group-based intervention, was associated with significant reductions in adolescents' willingness to use TNPs in a sample of 9th grade students. Changes in perceptions of harm and addictiveness were seen for the majority of TNPs as well as all adolescent by willingness and use groups (students without a willingness to use tobacco, students with a willingness to use tobacco, and students who use tobacco), suggesting that UP2UTeacher is a promising universal, brief intervention to address TNP perceptions and motivations in schools.

Indexed as

StudentsTobacco UseAdolescentFemaleHumansMaleSchoolsAdolescentsE-cigarettesNicotine productsTobacco cessationTobacco prevention

Identifiers

PMID42612334
PMCPMC13539533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.