ArticlePLoS computational biology2026
The SATvac model of CD8+ T cell expansion and contraction phases considering memory and effector cell differentiation.
Article in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary immune responses induce CD8+ T cell responses characterized by activation via antigen presenting cells, expansion, differentiation into effector and memory phenotypes, and contraction resulting in long-term memory populations. In this study a mathematical stochastic agent-based model is developed to simulate all phases of the CD8+ T cell response following vaccination. Importantly, the model successfully captures the stochastic nature of T cell dynamics throughout the response. It predicts T cell population with high accuracy while addressing mouse-to-mouse variability, highlighting its robust predictive power. This predictive model aims to improve T cell vaccination strategies by both informing the biology of the T cell response and streamlining vaccine development.
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