ArticleGlobal spine journal2026
The Longitudinal Changes of Cervical Sagittal Alignment in a Non-surgical Cohort: A 12-Year Longitudinal Study.
Article in Global spine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comment on: "The Longitudinal Changes of Cervical Sagittal Alignment in a Non-Surgical Cohort: A 12-Year Longitudinal Study".Global spine journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Study DesignA retrospective longitudinal observational cohort study.ObjectiveThis study aimed to quantitatively evaluate the natural progression of cervical sagittal alignment parameters in non-surgical patients over a mean 12-year follow-up period, with a specific focus on age- and sex-related variations.MethodsRadiographic data were analyzed from 198 non-surgical patients (mean age: 50.6 years) over a mean follow-up duration of 142 months (range: 96-203 months). Key parameters measured included C2-7 Cobb angle, range of motion (ROM), cervical sagittal vertical axis (SVA), T1 slope, C7 slope, thoracic inlet angle (TIA), and neck tilt. Longitudinal changes were evaluated alongside the influences of age and sex.ResultsThe cohort exhibited significant, age-accelerated progression in cervical sagittal alignment. Overall cervical ROM decreased markedly from 50.10° to 41.14° (P<0.001). Concurrently, a progressive trend toward anterior sagittal imbalance was observed, characterized by significant increases in C7 slope, T1 slope (24.86° to 26.41°), TIA, and SVA (22.38 mm to 24.59 mm). In contrast, the C2-7 Cobb angle and neck tilt remained stable. Advanced age was a strong independent predictor of deterioration. Furthermore, males experienced significantly greater reductions in ROM and more pronounced increases in SVA compared to females.ConclusionThe natural aging process of the cervical spine is characterized by progressive stiffening and a trajectory toward anterior sagittal malalignment, primarily mediated through a compensatory increase in T1 slope that is not matched by a reciprocal increase in lordosis. These data highlight the need to account for natural physiological drift when evaluating ultra-long-term iatrogenic surgical effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.