Evidence map›Paper›PMID 42611591›Full record

ArticleCritical care explorations2026

Association Between Community-Level Social Determinants of Health and Sepsis Incidence and Mortality: A Scoping Review.

Sahil Angelo, Fatima Sheikh, Maniraj Neupane, Sushil Pant, Elena Puccio, Christopher Schumacher, Alyson Lee, Swetha Jasti, Christina F Mair, Diane Cooper and 1 more

Abstract readScoping Review
In one paragraph

Article in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sahil AngeloCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.ORCID 0009-0000-9034-4007
Fatima SheikhDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Maniraj NeupanePrairie Center Medical Clinic and Grand Island Regional Medical Center, Bryan Health, Grand Island, NE.
Sushil PantDivision of Pulmonary, Critical Care and Sleep Medicine, Loma Linda University, Loma Linda, CA.
Elena PuccioUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Christopher SchumacherUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Alyson LeeUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Swetha JastiUniversity of Pittsburgh School of Medicine, Pittsburgh, PA.
Christina F MairDepartment of Behavioral and Community Health Sciences, University of Pittsburgh School of Public Health, Pittsburgh, PA.
Diane CooperOffice of Research Services, Division of Library Services, National Institutes of Health, Bethesda, MD.
Kristina E RuddCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

Funding

Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
The Syndemic of Sepsis, Multimorbidity, Aging, and Low Healthcare Access and Quality in the United StatesK23GM141463 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUDD, KRISTINA ELIZABETH · 2021 to 2025
$921k
NHLBI NIH HHS T32 HL007820NIGMS NIH HHS K23 GM141463
6 · The paper itself

Abstract

objectivesTo summarize the research methods, patient populations, and measures used to examine the associations between community-level social determinants of health (SDoH) and sepsis risk, and to describe the findings of the current evidence. DATA SOURCES: PubMed, Embase, Web of Science, Global Health, Cochrane Library, Scopus, Web of Science-Core Collection, and Latin American and Caribbean Literature on Health Sciences Database from January 1, 1991, to October 31, 2024. STUDY SELECTION: Studies were included if they evaluated the quantitative association between at least one community-level SDoH, measured at a spatial level smaller than a country and larger than a household, and sepsis incidence and/or mortality. DATA EXTRACTION: Titles, abstracts, and full-text articles were independently screened in duplicate. Data extraction was performed in duplicate using a standardized form capturing study design, sepsis definition, patient population, community-level SDoH domains, and outcomes. DATA SYNTHESIS: Of the 10,504 studies retrieved, 63 studies were included in the final analysis. The majority of studies (n = 39, 62%) were published between 2020 and 2024. Children (n = 10, 16%) and people in low- or middle-income countries (n = 9, 14%) were the least represented study populations. The most common domains of evaluated SDoH were demographic (n = 31, 49%), health access (n = 17, 27%), and economic (n = 16, 25%), with the most frequent variables being rurality (n = 24, 40%) and median household income by ZIP code (n = 10, 16%). There were 10 (16%) prospective cohort studies, 43 (68%) retrospective cohort, 6 (10%) case-control, and 4 (6%) ecological. Most studies (n = 54, 86%) reported a significant association between at least one community-level SDoH and sepsis incidence and/or mortality.

conclusionsThere is a growing but heterogeneous body of evidence on the associations between community-level SDoH and sepsis risk. Future research requires better representation from populations with the highest sepsis burden, more consistent definitions, and more rigorous, innovative methods to elucidate the mechanisms driving associations between multiple community-level SDoH and sepsis.

Indexed as

SepsisSocial Determinants of HealthHumansIncidenceSocioeconomic Disparities in Healthcommunity-level determinantsdisparitieshealth equitysepsissocial determinants

Identifiers

PMID42611591
PMCPMC13485937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.