ArticleAnalytical and bioanalytical chemistry2026
Development and validation of an LC-MS/MS method for the comprehensive quantification of tamoxifen and its metabolites in volumetric absorptive microsampling: clinical application in breast cancer patients.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tamoxifen requires biotransformation into metabolites to exert antiestrogenic activity, and variability in metabolite exposure contributes to interindividual differences in clinical outcomes. Volumetric absorptive microsampling (VAMS) provides a convenient and minimally invasive alternative for therapeutic drug monitoring (TDM). However, analytical methods enabling comprehensive quantification of tamoxifen and its metabolites in VAMS remain limited, and translation of VAMS-derived concentrations into plasma-equivalent values has not been well established. In this study, an LC-MS/MS method was developed and fully validated for simultaneous quantification of tamoxifen and six metabolites in VAMS samples. Water prerinsing prior to methanol extraction improved analyte recoveries to 89.2-111.2%. Stability evaluation of VAMS samples revealed poor room-temperature stability for most analytes, whereas all analytes remained stable for at least 100 days at -80 °C. Experimentally derived plasma-to-blood concentration ratios (C
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