Evidence map›Paper›PMID 42611261›Full record

ArticleSurgery today2026

Risk factors for infectious complications and postoperative outcomes of colorectal cancer patients with liver cirrhosis: a multicenter retrospective study.

Toshio Shiraishi, Tetsuro Tominaga, Koki Wakata, Masato Nishimuta, Masaki Utsugi, Hidetoshi Fukuoka, Mitsutoshi Ishii, Keisuke Noda, Shintaro Hashimoto, Kaido Oishi and 5 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toshio ShiraishiDepartment of Surgery, Isahaya General Hospital, 24-1 Isahaya, Nagasaki, 854-8501, Japan.
Tetsuro TominagaDepartment of Surgery, Isahaya General Hospital, 24-1 Isahaya, Nagasaki, 854-8501, Japan.
Koki WakataDepartment of Surgery, Isahaya General Hospital, 24-1 Isahaya, Nagasaki, 854-8501, Japan.
Masato NishimutaDepartment of Surgery, Isahaya General Hospital, 24-1 Isahaya, Nagasaki, 854-8501, Japan.
Masaki UtsugiDepartment of Surgery, Isahaya General Hospital, 24-1 Isahaya, Nagasaki, 854-8501, Japan.
Hidetoshi FukuokaDepartment of Surgery, Isahaya General Hospital, 24-1 Isahaya, Nagasaki, 854-8501, Japan.
Mitsutoshi IshiiDivision of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Keisuke NodaDivision of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Shintaro HashimotoDepartment of Surgery, Sasebo City General Hospital, 9-3 Hirasemachi, Nagasaki, 857-8511, Japan.
Kaido OishiDepartment of Surgery, National Hospital Organization Nagasaki Medical Center, 1-1001-1, Omura, Nagasaki, 856-8562, Japan.
Fumitake UchidaDepartment of Surgery, Ureshino Medical Center, 4279-3 Ko, Ureshinomachi, Ureshino, Oaza, Shimojuku, Saga 843-0393, Japan.
Shosaburo OyamaDepartment of Surgery, Saiseikai Nagasaki Hospital, 2-5-1 Katafuchi, Nagasaki, 850-0003, Japan.
Keizaburo MaruyamaDepartment of Surgery, Saseno Chuo Hospital, 15 Yamatocho, Sasebo, 857-1195, Japan.
Takashi NonakaDivision of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. tnonaka@nagasaki-u.ac.jp.
Keitaro MatsumotoDivision of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the clinicopathological characteristics and postoperative outcomes of colorectal cancer (CRC) patients with preoperative liver cirrhosis (LC), using a multicenter database.

methodsThe subjects of this retrospective study were 6,012 patients who underwent colorectal surgery between 2016 and 2025. The patients were divided into an LC group (n = 44) and a no-LC group (n = 5,968). We analyzed their perioperative outcomes and risk factors for infectious complications.

resultsThe LC group had significantly greater blood loss (40 mL vs. 20 mL, p < 0.001), higher rates of overall postoperative complications (52.3% vs. 18.4%, p < 0.001), and higher 30-day mortality (9.1% vs. 0.3%, p < 0.001) than the no-LC group. Infectious complications were also more frequent in the LC group (43.2% vs. 9.3%, p < 0.001). Multivariate analysis identified LC as a strong independent predictor of postoperative infectious complications (OR 6.780; 95% CI 3.663-12.548; p < 0.001). Notably, there were no 30-day deaths at facilities with dedicated intensive care unit (ICU) intensivists.

conclusionsPatients with advanced CRC are at high risk of complications from infections, which can result in a poor short-term prognosis. Thus, thorough preoperative evaluation and referral to a treatment facility with a well-established perioperative management system are essential for these high-risk patients.

Indexed as

Colorectal cancerInfectious complicationsLiver cirrhosis

Identifiers

PMID42611261

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