ArticleACS nano2026
Polydopamine Nanotubes: Multifunctional Smart Nanotransducers for Cellular Activity Modulation.
Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
14 authors.
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Abstract
Polydopamine nanotubes (PDA-NTs) represent a recently developed and scarcely explored class of nanostructures with exceptional multifunctionality. Synthesized through a ZnO-templated Stöber-like process followed by template removal, PDA-NTs exhibit a combination of piezoelectric, photothermal, and antioxidant properties, a collection of features never observed together in a single organic nanoparticle. This work provides the demonstration of electromechanical conversion in polydopamine structures, with PDA-NTs showing a robust piezoelectric coefficient (d33 = 15.0 ± 0.7 pC/N), a property completely absent in spherical PDA nanoparticles. PDA-NTs are efficiently internalized by cells and display excellent biocompatibility; upon remote stimulation, they can modulate intracellular calcium levels via ultrasound-driven activation or near-infrared (NIR) photothermal heating. In addition, their strong antioxidant capacity mitigates oxidative stress, while controlled dopamine release (both passive and ultrasound-triggered) induces functional effects in human neural stem cells. This unique combination of mechanical and NIR responsiveness, antioxidant activity, and neuromodulatory drug release within a single organic nanostructure marks a significant breakthrough, allowing PDA-NTs to emerge as a unique class of "smart" multifunctional nanomaterials, enabling remote cellular control and offering exciting opportunities for regenerative medicine, neurostimulation, and advanced bioelectronics.
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