Evidence map›Paper›PMID 42611193›Full record

SynthesisSkeletal radiology2026

Imaging-based prevalence of the peroneus quartus muscle and its association with peroneal tendon pathology: a systematic review and meta-analysis.

Luiza Borba de Almeida Madruga, Pandora Eloa Oliveira Fonseca, Giovanna Macanhã Scremin, Marco Aurelio Soato Ratti, João Paulo Costa Coelho, Mariana Jungles Polato, Edgar Leonardo Martinez Salazar

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luiza Borba de Almeida MadrugaDepartment of Radiology, Beth Israel Deaconess Medical Center (BIDMC), 330 Brookline Avenue, Boston, MA, 02215, USA. lmadruga@bidmc.harvard.edu.ORCID http://orcid.org/0009-0001-2565-4970
Pandora Eloa Oliveira FonsecaUniversidade Federal de Campina Grande (UFCG), Cajazeiras, PB, Brazil.
Giovanna Macanhã ScreminPontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Marco Aurelio Soato RattiUTHealth Houston, Houston, TX, USA.
João Paulo Costa CoelhoOne Laudos Diagnósticos Médicos, São Paulo, SP, Brazil.
Mariana Jungles PolatoFaculdades Pequeno Príncipe, Curitiba, PR, Brazil.
Edgar Leonardo Martinez SalazarDepartment of Radiology, Beth Israel Deaconess Medical Center (BIDMC), 330 Brookline Avenue, Boston, MA, 02215, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the imaging-based prevalence of the peroneus quartus muscle and to quantify concurrent peroneal tendon pathology among individuals with this anatomical variant. MATERIALS AND

methodsA systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. PubMed, EMBASE and Cochrane were searched from inception to 2025 for imaging-based studies reporting peroneus quartus prevalence. Overall prevalence was estimated using generalized linear mixed models with random effects. Heterogeneity was assessed using the I² statistic. Risk of bias was evaluated using design-specific Joanna Briggs Institute critical appraisal checklists. Subgroup analyses examined sex and laterality distribution among positive cases.

resultsSeventeen studies comprising 3,725 ankle imaging examinations were included. The overall prevalence of the peroneus quartus was 11% (95% CI: 8-15%), with substantial heterogeneity (I² = 80.5%). Among six studies (315 positive ankles), peroneal tendon pathology was present in 51.4% (95% CI: 41.9-60.8%). In three studies reporting tears in ankles with and without the peroneus quartus, its presence was associated with higher odds of peroneal tendon tears (pooled odds ratio 3.40, 95% CI: 2.03-5.68; I² = 0%; p < 0.001). The majority of studies (58.8%) were classified as low risk of bias.

conclusionThe peroneus quartus muscle is identified in approximately one of nine ankle imaging examinations, and in studies with a comparison group its presence was associated with higher odds of peroneal tendon tears. This supports the proposed crowding-effect hypothesis, although a causal relationship remains to be established.

Indexed as

Ankle InjuriesAnkle JointMuscle, SkeletalTendon InjuriesHumansPrevalenceAnkleFibularis quartusMeta-analysisMRIPeroneal tendonPeroneus quartusPrevalence

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.