Evidence map›Paper›PMID 42611158›Full record

ArticleInfection2026

Hematogenous vertebral osteomyelitis caused by vaginal microbiota: metagenomic resolution of a polymicrobial anaerobic case.

Isabelle Vock, Annika Bargetzi, Maja Weisser, Olivia Katharina Mueller, Milena Junker, Arne Mehrkens, Claudio Neidhoefer, Baptiste Hamelin, Salome Hosch, Kirsten D Mertz and 2 more

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Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Isabelle Vock *Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland.
Annika Bargetzi *Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland.
Maja WeisserDivision of Infectious Diseases, University Hospital Basel, Basel, Switzerland.
Olivia Katharina MuellerDepartment of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Milena JunkerDepartment of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Arne MehrkensDivision of Spine Surgery, University Hospital Basel, Basel, Switzerland.
Claudio NeidhoeferClinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
Baptiste HamelinInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Salome HoschInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Kirsten D MertzInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Peter M KellerClinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
Richard KuehlDivision of Infectious Diseases, University Hospital Basel, Basel, Switzerland. richardalexander.kuehl@usb.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a rare case of a 35-year-old female patient suffering from polymicrobial hematogenous vertebral osteomyelitis caused by vaginal microbiota following sexual intercourse. Anaerobic blood cultures yielded Fannyhessea vaginae and Gemelliphila asaccharolytica, and intraoperative tissue cultures from decompression surgery identified Gardnerella vaginalis. Beyond Fannyhessea vaginae and Gemelliphila asaccharolytica, 16S rRNA gene Nanopore sequencing of surgical tissue also detected high amounts of Parvimonas parva, Peptostreptococcus anaerobius, Marseillibacter massiliensis, and Gemelliphila palaticanis. Antibiotic treatment with broad anaerobic coverage resulted in complete clinical resolution. Retrospective metagenomic analysis of a cervical swab obtained 9 months earlier revealed Fannyhessea vaginae and G. vaginalis to be already present in the vaginal microbiota. This case highlights the potential for hematogenous dissemination of vaginal anaerobes after sexual intercourse and underscores the diagnostic challenges posed by fastidious anaerobic bacteria. Molecular techniques are helpful tools in uncovering pathogens that may escape conventional culture methods.

Indexed as

16S rRNA sequencingAnaerobic bacteriaFannyhessea vaginaeGardnerella vaginalisMetagenomic next-generation sequencingSpondylodiscitisVaginal microbiotaVertebral osteomyelitis

Identifiers

PMID42611158

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.