ArticleCurrent microbiology2026
Genomic Characterization of a Rare Methicillin-Susceptible Staphylococcus aureus ST72 Isolate Co-Harboring Panton-Valentine Leukocidin and Toxic Shock Syndrome Toxin-1 Encoding Genes from Northern Vietnam.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus (S. aureus) possesses a diverse repertoire of virulence determinants that enable it to cause pathologies that span from mild, superficial skin and soft tissue involvements to severe, life-threatening systemic infections. Among these, Panton-Valentine leucocidin and toxic shock syndrome toxin-1 are important toxins associated with severe clinical manifestations. However, the coexistence of their encoding genes (pvl and tst) within a single S. aureus isolate is uncommon. In this study, 112 clinical S. aureus isolates collected at a hospital in northern Vietnam were screened for pvl and tst by PCR. The pvl gene was identified in 88 isolates (78.57%), whereas tst was present in 12 isolates (10.71%). Only a single isolate carried both virulence markers. Whole-genome sequencing identified this isolate, designated SA14HG, as an ST72 methicillin-susceptible S. aureus (MSSA) strain carrying pvl, tst, multiple hemolysins, adhesion-associated genes, immune evasion determinants, and the complete icaADBC biofilm operon. Comparative genomic analysis demonstrated that SA14HG clustered within the global ST72 lineage and harbored a ΦSa2-like prophage carrying pvl together with a SaPI-like pathogenicity island encoding tst, Sect. 3, and sel. Despite its extensive virulence repertoire, the isolate contained a relatively limited resistome comprising genes associated with resistance to β-lactams, aminoglycosides, and fosfomycin. Collectively, these findings describe a rare pvl/tst co-positive ST72-MSSA strain recovered from a patient with severe purulent dermatitis and underscore the utility of whole-genome sequencing for identifying uncommon toxin-positive lineages. The study further highlights the contribution of mobile genetic elements to the ongoing evolution of community-associated S. aureus populations.
Indexed as
Identifiers
42611094What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.