ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Mechanisms and therapeutic potential of therapy-induced cellular senescence in radiotherapy- and chemotherapy-related alimentary tract mucositis.
Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
purposeRadiotherapy- and chemotherapy-related alimentary tract mucositis is a common complication of cancer treatment, yet the role of cellular senescence during these treatments and post-treatment mucosal repair has not been systematically discussed. This narrative review summarizes the potential involvement of therapy-induced cellular senescence (TIS) in cumulative mucosal injury during treatment and in post-treatment healing and remodeling, and discusses the therapeutic potential and limitations of targeting senescence.
methodsThis narrative review synthesizes evidence from studies on TIS, SASP biology, oral and gastrointestinal mucositis, oxidative stress, extracellular matrix remodeling, microbial dysbiosis, mucosal wound repair, and senescence-targeted interventions.
resultsTIS may amplify mucosal injury during treatment by sustaining ROS accumulation and oxidative stress, contributing to extracellular matrix remodeling, and promoting dysbiosis-prone mucosal microecological remodeling. During post-treatment healing, transient senescence may support immune recruitment, debris clearance, and repair initiation, whereas persistent senescence may maintain inflammatory SASP signaling, impair epithelial regeneration, and promote abnormal tissue remodeling. These processes may operate in both oral and gastrointestinal mucositis, but their dominant cellular sources, microbial interfaces, and repair programs are likely organ-specific. Current experimental evidence also suggests that senescence-targeted strategies may attenuate mucosal injury, although their timing and safety remain critical issues.
conclusionTIS may contribute to both the cumulative injury phase during treatment and the healing and remodeling phase after treatment in alimentary tract mucositis. Senescence-targeted strategies have therapeutic potential, but their translation requires careful consideration of intervention timing, local delivery, tumor safety, and preservation of early repair-promoting senescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.